diff --git a/caddytest/integration/caddyfile_adapt/reverse_proxy_handle_response_too_many_args.caddyfiletest b/caddytest/integration/caddyfile_adapt/reverse_proxy_handle_response_too_many_args.caddyfiletest
new file mode 100644
index 000000000..5bc3121c3
--- /dev/null
+++ b/caddytest/integration/caddyfile_adapt/reverse_proxy_handle_response_too_many_args.caddyfiletest
@@ -0,0 +1,10 @@
+localhost:8884 {
+	reverse_proxy localhost:8000 {
+		handle_response header Foo {
+			respond "handled"
+		}
+	}
+}
+
+----------
+parsing caddyfile tokens for 'reverse_proxy': too many arguments for 'handle_response': only a single response matcher name is allowed, but got: [header Foo]
diff --git a/modules/caddyhttp/reverseproxy/caddyfile.go b/modules/caddyhttp/reverseproxy/caddyfile.go
index 8716babe3..4661f8863 100644
--- a/modules/caddyhttp/reverseproxy/caddyfile.go
+++ b/modules/caddyhttp/reverseproxy/caddyfile.go
@@ -923,13 +923,8 @@ func (h *Handler) FinalizeUnmarshalCaddyfile(helper httpcaddyfile.Helper) error
 		d.Next()
 		args := d.RemainingArgs()
 
-		// TODO: Remove this check at some point in the future
-		if len(args) == 2 {
-			return d.Errf("configuring 'handle_response' for status code replacement is no longer supported. Use 'replace_status' instead.")
-		}
-
 		if len(args) > 1 {
-			return d.Errf("too many arguments for 'handle_response': %s", args)
+			return d.Errf("too many arguments for 'handle_response': only a single response matcher name is allowed, but got: %s", args)
 		}
 
 		var matcher *caddyhttp.ResponseMatcher